The cardiac arrhythmia suppression trial: First CAST … then CAST-II
نویسندگان
چکیده
منابع مشابه
Events in the Cardiac Arrhythmia Suppression Trial (CAST): mortality in the entire population enrolled.
To test the hypothesis that suppression of ventricular arrhythmias by antiarrhythmic drugs after myocardial infarction improves survival, the Cardiac Arrhythmia Suppression Trial (CAST) was initiated. Suppression was evaluated before randomization during an open label titration period. Patients whose arrhythmias were suppressed were randomized in the main study and those whose arrhythmias were ...
متن کاملConsensus Statement CAST and Beyond Implications of the Cardiac Arrhythmia Suppression Trial
F requent and repetitive forms of premature ventricular complexes (PVCs) have been recognized as independent markers of increased risk for sudden cardiac death in patients with a previous myocardial infarction. On this basis, the Cardiac Arrhythmic Suppression Trial (CAST) was initiated to test the hypothesis that suppression of these ventricular arrhythmias would reduce the incidence of sudden...
متن کاملA Possible Explanation for Increased Mortality in the Cardiac Arrhythmia Suppression Trial (CAST)
Background The Cardiac Arrhythmia Suppression Trial (CAST) was designed to test the hypothesis that suppression of ventricular ectopy with antiarrhythmic drugs after a myocardial infarction reduces the incidence of sudden arrhythmic death. Patients in whom ventricular ectopy could be suppressed with encainide, flecainide, or moricizine were randomly assigned to receive either active drug or pla...
متن کاملPatients With Myocardial Infarction A Possible Explanation for Increased Mortality in the Cardiac Arrhythmia Suppression Trial (CAST)
Background The Cardiac Arrhythmia Suppression Trial (CAST) was designed to test the hypothesis that suppression of ventricular ectopy with antiarrhythmic drugs after a myocardial infarction reduces the incidence of sudden arrhythmic death. Patients in whom ventricular ectopy could be suppressed with encainide, flecainide, or moricizine were randomly assigned to receive either active drug or pla...
متن کاملLessons from the cardiac arrhythmia suppression trial.
Deaths increased in patients given encainide orflecainide The cardiac arrhythmia suppression trial (CAST) was designed in the United States to test the hypothesis that suppressing asymptomatic ventricular premature beats with antiarrhythmic drugs reduces the risk of death from arrhythmia after myocardial infarction. The three drugs studied (encainide, flecainide, and moricizine) were chosen bec...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1992
ISSN: 0735-1097
DOI: 10.1016/0735-1097(92)90267-q